Synthesis and fungicidal activity of some sulphide derivatives of O-phenyl-N-substituted phenylcarbamates

Monosulphides of O-phenyl-N-substituted phenylcarbamates were prepared by the reaction between Ophenyl-N-substituted phenylcarbamates and sulphur dichloride while the corresponding disulphides were prepared by the reaction between O-phenyl-Nsubstituted phenylcarbamates and sulphur monochloride. The synthesized compounds were characterized by elemental analysis, thin layer chromatography (TLC), Fourier-transform infrared, H and C nuclear magnetic resonance spectroscopic techniques. In vitro fungicidal assay of these sulphides against Fusarium oxysporum, Aspergillus niger, Aspergillus flavus and Rhizopus stolonifer showed that they were more fungicidal than their parent carbamates. The synthesized sulphides were more active towards Aspergillus niger and Aspergillus flavus. There was little or no variations in the fungicidal activities of the synthesized monosulphides and disulphides of O-phenyl-N-substituted phenyl carbamates.